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The CD94/NKG2 C-type lectin receptor complex

✍ Scribed by Miguel López-Botet; Marta Carretero; Juan J. Pérez-Villar; Teresa Bellón; Manuel Llano; Francisco Navarro


Publisher
Springer-Verlag
Year
1997
Tongue
English
Weight
879 KB
Volume
16
Category
Article
ISSN
0257-277X

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## Abstract A subset of CD8^+^ T cells express the natural killer cell receptors CD94:NKG2A or CD94:NKG2C. We found that although many CD8^+^ T cells transcribe CD94 and NKG2C, expression of a functional CD94:NKG2C receptor is restricted to highly differentiated effector cells. CD94:NKG2A is expres

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Multiple NK cell receptors for MHC class I have been identified. They include killer inhibitory receptors and CD94/NKG2 heterodimers in humans and the Ly49 family in mice. Here we report the cloning of murine NKG2A, B and C. The deduced amino acid sequence of mouse NKG2A contains only one consensus