The CD40–CD154 system in anti-infective host defense

✍ Scribed by Iqbal S Grewal; Persephone Borrow; Eric G Pamer; Michael BA Oldstone; Richard A Flavell

• Book ID: 104358723
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 641 KB
• Volume: 9
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(97)80100-8

✦ Synopsis

Research in the past few years has documented significant advances in our understanding of the CD40-CD40 ligand (CD154) system in diverse immune functions. This system influences many T cell mediated inflammatory immune responses and effector functions, unmasking a previously unexpected role for CD40-CD154 in cell mediated immunity. Manipulation of CD154 in animal models of infection by the use of CD154-deficient mice or anti-CD154 antibodies has shown the importance of this system in the initiation of the inflammatory response, in the activation of antigen-presenting cells and in resistance to infections.