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The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells

✍ Scribed by Creg J. Workman; Dario A. A. Vignali


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
317 KB
Volume
33
Category
Article
ISSN
0014-2980

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## Abstract CD4 binds to MHC class II molecules and enhances T‐cell activation. The CD4‐related transmembrane protein LAG‐3 (lymphocyte activation gene‐3, CD223) binds to the same ligand but inhibits T‐cell proliferation. We have previously shown that LAG‐3 cell surface expression is tightly regula