CD223 (LAG-3) is an activation-induced cell surface molecule, structurally similar to the T cell coreceptor CD4, that binds MHC class II molecules with high affinity. Little is known about the expression and function of murine CD223. Here, we show that mRNA expression is restricted to the thymic med
The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells
✍ Scribed by Creg J. Workman; Dario A. A. Vignali
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 317 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0014-2980
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## Abstract CD4 binds to MHC class II molecules and enhances T‐cell activation. The CD4‐related transmembrane protein LAG‐3 (lymphocyte activation gene‐3, CD223) binds to the same ligand but inhibits T‐cell proliferation. We have previously shown that LAG‐3 cell surface expression is tightly regula