## Abstract CCL5 (previously called RANTES) is in the CC‐chemokine family and plays a crucial role in the migration and metastasis of human cancer cells. On the other hand, the effect of CCL5 is mediated via CCR receptor. RT‐PCR and flow cytometry studies demonstrated CCR5 but not CCR1 and CCR3 mRN
✦ LIBER ✦
The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts
✍ Scribed by Chih-Hsin Tang; Chin-Jung Hsu; Yi-Chin Fong
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 362 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0004-3591
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## Abstract The production of chemokine stromal cell‐derived factor (SDF)‐1 is significantly higher in synovial fluid of patients with osteoarthritis (OA). IL‐6 is a multifunctional cytokine that plays a central role in both OA and rheumatoid arthritis. However, the effects of SDF‐1α on human synov