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The catalytic mechanism of protein tyrosine phosphatases revisited

✍ Scribed by Karin Kolmodin; Johan Åqvist

Book ID
117103035
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
127 KB
Volume
498
Category
Article
ISSN
0014-5793

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Protein-tyrosine kinases (PTKs) and their associated signaling pathways are crucial for the regulation of numerous cell functions including growth, mitogenesis, motility, cell-cell interactions, metabolism, gene transcription, and the immune response. Since tyrosine phosphorylation is reversible and