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The castor oil test in rats: An in vivo method to evaluate antipropulsive and antisecretory activity of antidiarrheals?

✍ Scribed by Dr. Sc. C. J. E. Niemegeers; F. Awouters; P. A. J. Janssen

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 263 KB
Volume: 4
Category: Article
ISSN: 0272-4391
DOI: 10.1002/ddr.430040211

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✦ Synopsis

Castor oil-induced diarrhea in rats is described to be an appropriate model of the complex, prolonged processes of hypersecretion and accelerated transit that characterize secretory diarrhea. Suprofen, a prostaglandin biosynthesis inhibitor, was found to postpone diarrhea over a wide dose range, but suprofen failed to reduce the diarrheal excretion. In contrast to suprofen, loperamide not only increased the diarrhea-free period but also produced a dose-related decrease of the diarrheal excretion.

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