The case for an empirical 'high-throughput' neutron scattering approach to protein dynamics

✍ Scribed by Zaccai, Giuseppe (author)

• Publisher: International Union of Crystallography
• Year: 2010
• Tongue: English
• Weight: 85 KB
• Volume: 66
• Category: Article
• ISSN: 0907-4449
• DOI: 10.1107/s0907444910021086

✦ Synopsis

Recalling that there are currently more than 63,000 structures deposited in the Protein Data Bank, it is time for neutron scatterers studying protein dynamics to show a similar interest in the diversity that is the basis of biology. Sound experimental data that can underpin and complement molecular-dynamics simulations for fundamental research and health applications such as drug design can and should be provided. A proposal is presented to fulfil the two conditions that are required to enable such an approach: (i) the identification of measurable dynamics parameters that are correlated to biological function and activity and (ii) the design of experiments to measure these parameters efficiently with reasonable throughput.