The cardiovascular response to digoxin in conscious dogs with left atrial obstruction

✍ Scribed by Heerdt, Paul M.; Caldwell, Robert W.

• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 534 KB
• Volume: 4
• Category: Article
• ISSN: 0888-6296
• DOI: 10.1016/s0888-6296(09)90005-9

✦ Synopsis

In addition to positive inotropic and atrioventricular conduction-blocking properties. digoxin is capable of producing systemic and pulmonary vasoconstriction. However. whether chronic digoxin treatment exacerbates the pulmonary hypertension that results from left atrial (LA) outflow obstruction has not been specifically examined. This study assessed the vascular and inotropic responses to 5 days of digoxin treatment in six conscious dogs before and after filling a permanently implanted LA balloon. Dogs were also instrumented to measure left ventricular (LV) pressure, LV dP I dt. mean systemic arterial (MAP). right atrial (RAP). pulmonary arterial. and pulmonary capillary wedge pressures. as well as cardiec output (CO). Under normal conditions with the balloon empty. digoxin treatment (40 Ilg/kg