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The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium

โœ Scribed by C. A. Remme; A. O. Verkerk; W. M. H. Hoogaars; W. T. J. Aanhaanen; B. P. Scicluna; C. Annink; M. J. B. van den Hoff; A. A. M. Wilde; T. A. B. van Veen; M. W. Veldkamp; J. M. T. de Bakker; V. M. Christoffels; C. R. Bezzina


Book ID
106067149
Publisher
Springer
Year
2009
Tongue
English
Weight
795 KB
Volume
104
Category
Article
ISSN
0300-8428

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Voltage-gated sodium channels underlie the generation of action potentials in excitable cells. Various sodium channel isoforms have been cloned, functionally expressed and distinguished on the basis of their biophysical properties or differential sensitivity to tetrodotoxin (TTX). In the present stu