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The carboxyl-terminal domains of MKP-1 and MKP-2 have inhibitory effects on their phosphatase activity

✍ Scribed by Dorothy Hutter; Peili Chen; Janice Barnes; Yusen Liu


Book ID
110337361
Publisher
Springer
Year
2002
Tongue
English
Weight
336 KB
Volume
233
Category
Article
ISSN
0300-8177

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## Abstract Src homology 2 (SH2)‐domain‐mediated interactions with phosphotyrosine (pY)‐containing ligands are critical for the regulation of SHP‐1 phosphatase activity. Peptides based on a binding site from receptor tyrosine kinase Ros (EGLN‐pY2267‐MVL, 1) have recently been shown to bind to the S