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The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

✍ Scribed by Jarrett, Joseph T.; Berger, Elizabeth P.; Lansbury, Peter T.


Book ID
120299972
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
593 KB
Volume
32
Category
Article
ISSN
0006-2960

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## Abstract The etiology of Alzheimer's disease (AD) involves a significant inflammatory component as evidenced by the presence of elevated levels of a diverse range of proinflammatory molecules in the AD brain. These inflammatory molecules are produced principally by activated microglia, which are