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The carboxy-terminal pleckstrin homology domain of ROCK interacts with filamin-A

✍ Scribed by Kozue Ueda; Yasutaka Ohta; Hiroshi Hosoya


Book ID
117053298
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
220 KB
Volume
301
Category
Article
ISSN
0006-291X

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Structure of the carboxy-terminal PH dom
✍ Jackson, S. G. ;Zhang, Y. ;Bao, X. ;Zhang, K. ;Summerfield, R. ;Haslam, R. J. ;J πŸ“‚ Article πŸ“… 2006 πŸ› International Union of Crystallography 🌐 English βš– 672 KB

Pleckstrin is an important intracellular protein involved in the phosphoinositide-signalling pathways of platelet activation. This protein contains both N- and C-terminal pleckstrin-homology (PH) domains (N-PH and C-PH). The crystal structure of C-PH was solved by molecular replacement and refined a