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The carbonyl scavengers aminoguanidine and tenilsetam protect against the neurotoxic effects of methylglyoxal

✍ Scribed by Julie Webster; Christin Urban; Katrin Berbaum; Claudia Loske; Alan Alpar; Ulrich GÄrtner; Susana Garcia De Arriba; Thomas Arendt; Gerald MÜnch

Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
387 KB
Volume
7
Category
Article
ISSN
1029-8428

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✍ Jinyu Ma; Xiaofang Peng; Ka-Wing Cheng; Feng Chen; Dajin Yang; Bo Chen; Mingfu W 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 577 KB

## Abstract Methylglyoxal (MGO) is a highly reactive α‐oxoaldehyde formed endogenously in numerous enzymatic and nonenzymatic reactions. The reactions between MGO and various amino residues in proteins not only result in inactivation of enzymes, but also lead to the formation of different detriment