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The cannabinoid CB1 receptor antagonist SR141716A reduces appetitive and consummatory responses for food

✍ Scribed by Zoë D. Thornton-Jones; Steven P. Vickers; Peter G. Clifton

Publisher: Springer
Year: 2004
Tongue: English
Weight: 174 KB
Volume: 179
Category: Article
ISSN: 0033-3158
DOI: 10.1007/s00213-004-2047-8

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To characterize the behavioral and biochemical effects of the cannabinoid CB1 antagonist SR141716A, we injected the compound intraperitoneally (ip) at doses from 0.625 mg/kg to 5 mg/kg in rats. SR141716A per se induced a dose-dependent increase of some behavioral signs such as wet dog and head shake