## Communicated by Christine Van Broeckhoven Huntington disease (HD) is an autosomal dominant neurodegenerative disorder characterized clinically by progressive motor impairment, cognitive decline, and emotional deterioration. The disease is caused by the abnormal expansion of a CAG trinucleotide
✦ LIBER ✦
The CAG repeat at the Huntington disease gene in the Portuguese population: insights into its dynamics and to the origin of the mutation
✍ Scribed by Maria do Carmo Costa; Paula Magalhães; Laura Guimarães; Patrícia Maciel; Jorge Sequeiros; Alda Sousa
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 227 KB
- Volume
- 51
- Category
- Article
- ISSN
- 1435-232X
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## Abstract We report on a pair of monozygotic twins belonging to a family segregating Huntington disease (HD). In routine DNA analysis of blood cells, they displayed three alleles of the CAG repeat sequence in the HD gene. Two different cell lines, carrying the normal allele together with either a
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