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The Ca2+ binding capacity of epidermal furin is disrupted by H2O2-mediated oxidation in vitiligo

✍ Scribed by J. D. Spencer; N. C. J. Gibbons; M. Böhm; K. U. Schallreuter


Book ID
111244353
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
42 KB
Volume
17
Category
Article
ISSN
0906-6705

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We sought to investigate the mechanism(s) by which the oxidant H2O2 stimulates Ca2+ release from mitochondria of bovine pulmonary vascular smooth muscle tissue and to test the hypothesis that hydroxyl radical is involved in this phenomenon. Treatment of the smooth muscle tissue with 1 mM H2O2 dramat