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The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate

✍ Scribed by Janssens, Annelies; Owsianik, Grzegorz; Vennekens, Rudi; Voets, Thomas; Nilius, Bernd; Mahieu, Frank; Prenen, Jean


Book ID
110031348
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
555 KB
Volume
25
Category
Article
ISSN
0261-4189

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Very recently, mutations in the TRPM4 gene have been identified in four pedigrees as the cause of an autosomal dominant form of cardiac conduction disease. To determine the role of TRPM4 gene variations, the relative frequency of TRPM4 mutations and associated phenotypes was assessed in a cohort of