The C-terminal Ca2+-binding domain of SP
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Catherine F. Delostrinos; Amber E. Hudson; Waldo C. Feng; Jeffrey Kosman; James
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Article
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2005
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John Wiley and Sons
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English
⚖ 246 KB
## Abstract The anti‐spreading activity of secreted protein acidic and rich in cysteine (SPARC) has been assigned to the C‐terminal third domain, a region rich in α‐helices. This “extracellular calcium‐binding” (EC) domain contains two EF‐hands that each coordinates one Ca^2+^ ion, forming a helix‐