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The C-terminal Domain Revealed in the Structure of RNA Polymerase II

✍ Scribed by Gavin D. Meredith; Wei-Hau Chang; Yang Li; David A. Bushnell; Seth A. Darst; Roger D. Kornberg


Book ID
115627350
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
285 KB
Volume
258
Category
Article
ISSN
0022-2836

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The Ξ± subunit C-terminal domain (Ξ±CTD) of RNA polymerase (RNAP) is a key element in transcription activation in__Escherichia coli__, possessing determinants responsible for the interaction of RNAP with DNA and with transcription factors. Here, the crystal structure of__E. coli__Ξ±CTD (Ξ± subunit resid