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The C-terminal binding domain of hirullin P18: Antithrombin activity and comparison to hirudin peptides

โœ Scribed by John L. Krstenansky; Thomas J. Owen; Mark T. Yates; Simon J.T. Mao


Book ID
115924012
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
446 KB
Volume
269
Category
Article
ISSN
0014-5793

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The C-terminal Ca2+-binding domain of SP
โœ Catherine F. Delostrinos; Amber E. Hudson; Waldo C. Feng; Jeffrey Kosman; James ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 246 KB

## Abstract The antiโ€spreading activity of secreted protein acidic and rich in cysteine (SPARC) has been assigned to the Cโ€terminal third domain, a region rich in ฮฑโ€helices. This โ€œextracellular calciumโ€bindingโ€ (EC) domain contains two EFโ€hands that each coordinates one Ca^2+^ ion, forming a helixโ€