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The breast cancer susceptibility allele CHEK2*1100delC promotes genomic instability in a knock-in mouse model

✍ Scribed by El Mustapha Bahassi; C. Gail Penner; Susan B. Robbins; Elisia Tichy; Estrella Feliciano; Moying Yin; Li Liang; Li Deng; Jay A. Tischfield; Peter J. Stambrook


Book ID
113808973
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
658 KB
Volume
616
Category
Article
ISSN
0027-5107

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The breast cancer low-penetrance allele
✍ Ana Osorio; Raquel RodrΓ­guez-LΓ³pez; Orland DΓ­ez; Miguel de la Hoya; JosΓ© Ignacio πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 French βš– 127 KB πŸ‘ 2 views

## Abstract Searching for low‐penetrance genes involved in breast cancer susceptibility has been a field of interest in the last few years. Recently, the CHEK 2 gene, involved in DNA damage and replication checkpoints, has been pointed out as a good candidate; moreover, a specific variant in this g