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The Bloom's syndrome helicase suppresses crossing over during homologous recombination

✍ Scribed by Wu, Leonard; Hickson, Ian D.


Book ID
109892634
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
313 KB
Volume
426
Category
Article
ISSN
0028-0836

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Localization of the bloom syndrome helic
✍ Vazganoush Gharibyan; Hagop Youssoufian πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 475 KB πŸ‘ 2 views

The Bloom (BLM) and Werner's (WRN) syndrome proteins may regulate recombination and DNA repair. Using a novel polyclonal antibody to human BLM, we detected the 170-kda BLM antigen in wild-type but not Bloom syndrome cells. BLM was localized to punctate nuclear structures. The level of BLM but not WR