The blood-brain barrier ? the effect of acidic dissociation constant on the permeation of certain sulfonamides into the brain

✍ Scribed by Goldsworthy, Patrick D. ;Aird, Robert B. ;Becker, Ronald A.

• Publisher: Wiley (John Wiley & Sons)
• Year: 1954
• Tongue: English
• Weight: 446 KB
• Volume: 44
• Category: Article
• ISSN: 0095-9898
• DOI: 10.1002/jcp.1030440311

✦ Synopsis

Previous studies on the blood-brain barrier which have utilized cocaine as a tracer agent have indicated that the permeability of this barrier was increased in such conditions as cerebral concussion and electric shock therapy (Aird and Strait, '44; a i r d et al., in preparation; Aird et al., '52; Strait et al., '41). Since observations based upon a single tracer agent, however, do not permit general conclusions with respect to the permeability of the blood-brain barrier, it became desirable to compare these initial results obtained with cocaine, with results obtained with other tracer agents. This, in addition to the laboriousness of the cocaine analysis, led us to initiate studies of cerebrovascular permeability with other compounds.

A review of the literature strongly suggested a similar inadequacy in the techniques used in the majority of the previous studies that have been made on the blood-brain barrier. I t would appear that studies of the permeability of this important neurophysiological mechanism, based upon single tracers selected at random, niight contribute little to our understanding of the barrier function as a whole. The ques-