The Blood Brain Barrier and Inflammation

✍ Scribed by Ruth Lyck, Gaby Enzmann (eds.)

Publisher: Springer International Publishing
Year: 2017
Tongue: English
Leaves: 288
Series: Progress in Inflammation Research
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strictly separated from the CNS parenchyma by the BBB. However, viruses, bacteria, parasites and auto-aggressive immune cells can penetrate the barrier and significantly contribute to CNS inflammation. The BBB can actively contribute to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alterations of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential to the development of new drugs to efficiently combat inflammatory diseases of the CNS.

✦ Table of Contents

Front Matter....Pages i-vi
General Introduction to Barrier Mechanisms in the Central Nervous System....Pages 1-22
Topological Aspects of the Blood–Brain and Blood–Cerebrospinal Fluid Barriers and Their Relevance in Inflammation....Pages 23-48
The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions....Pages 49-60
Pathophysiology of the Blood–Brain Barrier in Neuroinflammatory Diseases....Pages 61-79
Leakage at Blood-Neural Barriers....Pages 81-102
Blood–Brain Barrier Transporters and Neuroinflammation: Partners in Neuroprotection and in Pathology....Pages 103-151
microRNAs in Brain Endothelium and Inflammation....Pages 153-173
Blood-Brain Barrier Dysfunction during Central Nervous System Autoimmune Diseases....Pages 175-186
Pathways Across the Blood-Brain Barrier....Pages 187-211
Neuroinflammation in Bacterial Meningitis....Pages 213-252
Blood Vessels in the Brain: A Signaling Hub in Brain Tumor Inflammation....Pages 253-277
Back Matter....Pages 279-286

✦ Subjects

Immunology;Neurosciences;Membrane Biology;Infectious Diseases;Cytokines and Growth Factors

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