The blood-brain barrier: an alternative hypothesis
โ Scribed by Isabel Lockard
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 647 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0022-5193
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## Abstract Few terms in the biomedical lexicon are as widely recognized as the phrase bloodโbrain barrier (BBB). Indeed, it immediately conjures up a โbarricadeโ between the blood and the brain, a feature often considered more obstacle than safeguard. In truth, the BBB performs in both capacities,
Defensins are small, cationic, cyclic peptides that are abundantly stored in granules of neutrophils. Defensins non-specifically interact with membranes by forming weakly ion-selective pores. Here we demonstrate immunolocalization of defensin-secreting cells in human brain. Defensins, secreted by ac