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The bivariate continual reassessment method: extending the CRM to phase I trials of two competing outcomes

โœ Scribed by Thomas M. Braun


Book ID
114186913
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
148 KB
Volume
23
Category
Article
ISSN
0197-2456

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Continual reassessment methods in phase
โœ Andrew Kramar; Anne Lebecq; Emmanuel Candalh ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 153 KB ๐Ÿ‘ 2 views

Most phase I trials in oncology use standard methods for treating successive groups of patients with increasing doses in order to determine the maximum tolerated dose (MTD). These methods have been criticized because they treat many patients at suboptimal dose levels, and do not provide an accurate