The biotechnological production of podophyllotoxin and related cytotoxic lignans by plant cell cultures
β Scribed by Uden, W.
- Publisher
- Springer
- Year
- 1993
- Tongue
- Dutch
- Weight
- 61 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1573-739X
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The bioconversion of the lignan desoxypodophyllotoxin by cell suspensions of Linumflavum and of Podophyllum hexandrum was investigated. The apolar substrate could be easily dissolved in the culture medium at a concentration of 2 mM by complexation with dimethyl-/~-cyclodextrin. Growth parameters of
In order to improve the production of the cytotoxic lignan podophyllotoxin, seven precursors from the phenylpropanoid-routing and one related compound were fed to cell suspension cultures derived from the rhizomes of Podophyllum hexandrum Royle. These cell cultures were able to convert only coniferi