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The biosynthesis of murayaquinone, a rearranged polyketide

✍ Scribed by Steven J. Gould; Chris R. Melville; Jiong Chen

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
344 KB
Volume
53
Category
Article
ISSN
0040-4020

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✦ Synopsis

Incorporations of sodium [1,2-13C2]acetate and sodium [l-13C,1802]acetate confirmed that murayaquinone, produced by Streptomyces murayamaensis, is a polyketide. However, the labeling patterns revealed that a simple folding of the decaketide intermediate does not lead directly to the final phenanthrene skeleton. Instead a different phenanthrene is apparently formed that undergoes an oxidative cleavage, isomerization, and re-closure to a new phenanthrene skeleton.

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