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The Biosynthesis of Indolocarbazoles in a Heterologous E. coli Host

✍ Scribed by Chang-Gu Hyun; Tsion Bililign; Jianchun Liao; Jon S. Thorson

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 104 KB
Volume: 4
Category: Article
ISSN: 1439-4227
DOI: 10.1002/cbic.200390004

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## Abstract 6‐Deoxyerythronolide B (6dEB) is the macrocyclic aglycone precursor of the antibiotic natural product erythromycin. Heterologous production of 6dEB in __Escherichia coli__ was accomplished, in part, by designed over‐expression of a native __prpE__ gene (encoding a propionyl‐CoA syntheta