The biological functions of low-frequency vibrations (phonons). VI. A possible dynamic mechanism of allosteric transition in antibody molecules
✍ Scribed by Kuo-Chen Chou
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1987
- Tongue
- English
- Weight
- 720 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0006-3525
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✦ Synopsis
289-2971, the low-frequency breathing motions of the /3-barrels in the 12 domains of an IgG antibody molecule have been calculated. The results are in very good agreement with the observed low-frequency peaks in the Raman spectra. Based on this, the resonant couplings among the domains located at its different regions are discussed. It turns out that some very interesting functions of antibody molecules, such as the "chelate effect" and "trigger effect" whose dynamic principle has been so far unknown, can be clearly elucidated in terms of a fundamental natural law; i.e., it is through the channel of low-frequency resonance that the ''signal'' (or energy) in an antibody is transmitted from one location to the other, so as to be able to induce the relevant conformational change required for operating those important biological functions. The physical picture illustrated here once again provides us with a classic example that structure and function in nature are highly harmonized.