✦ LIBER ✦

The biologic dilemma of early carcinoma of the prostate

✍ Scribed by Andrew C. von Eschenbach

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 414 KB
Volume: 78
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19960715)78:2<326::aid-cncr21>3.0.co;2-x

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✦ Synopsis

BACKGROUND.

The clinician has long been challenged by the diversity in clinical expression of carcinoma of the prostate. On one end of the spectrum is a disease that is phenotypically malignant but biologically not virulent. It is the prostate carcinoma that males die with rather than of. On the other end of the spectrum, there is a carcinoma of the prostate that is relentless and virulent, and has been resistant to our intervention efforts. Although all males are known to be at risk for the occurrence of carcinoma of the prostate, there is no means at present to predict the type and behavior of the disease they will experience. This is the conundrum faced upon recognition of premalignant and early microscopic disease.

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