The biography of psychiatric genetics: From early achievements to historical burden, from an anxious society to critical geneticists
✍ Scribed by Peter Propping
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 237 KB
- Volume
- 136B
- Category
- Article
- ISSN
- 1552-4841
No coin nor oath required. For personal study only.
✦ Synopsis
Establishing the psychiatric diagnosis may be problematic. * Psychiatric symptoms may only be epiphenomena, we need endophenotypes. * There is a high redundancy of CNS functions, therefore we can only expect small gene effects. * False positive findings may result from multiple testing. * Problems may arise from ethnic differences. Some non-scientific arguments: * Premature publication because of competition pressure. * Premature publication because of commercial interests. * Selective publication of positive findings. * Lower standard of investigators than in other fields of genetics.
* standardized definition of the phenotype, * minimal number of cases and controls, e.g. 300-500 in each group, * replication of a positive association finding in a second casecontrol-sample of the same sizes, * replication in a minimal number of trios, e.g. 150-200, * clear control of ethnicity of the included samples, * precise number of applied statistical comparisons so that the reader can judge its validity.
If we do not find solutions to the problem of multiple testing, selective publication, and ethnic stratification effects, we will