The biochemical properties of the mitochondrial thiamine pyrophosphate carrier from Drosophila melanogaster
β Scribed by Domenico Iacopetta; Chiara Carrisi; Giuseppina De Filippis; Valeria M. Calcagnile; Anna R. Cappello; Adele Chimento; Rosita Curcio; Antonella Santoro; Angelo Vozza; Vincenza Dolce; Ferdinando Palmieri; Loredana Capobianco
- Book ID
- 111313403
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 669 KB
- Volume
- 277
- Category
- Article
- ISSN
- 1432-1327
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The rudimentary (r) locus of Drosophila melanogaster encodes the first three enzymes for the de novo synthesis of pyrimidines: carbamyl phosphate synthase (CPSase), aspartyl transcarbamylase (ATCase), and dihydroorotase (DHOase). Revertants of leaky r mutants deficient in CPSase have been recovered.
The effects of six recessive visible Notch mutations on the activities of four enzymes of the mitochondrial respiratory chain are described. Their effects in hemizygous condition in males are similar to those of the recessive lethal Notch mutations in heterozygous condition. This explains their viab