The biochemical pharmacology of CI-920, a structurally novel antibiotic with antileukemic activity
โ Scribed by Robert C. Jackson; David W. Fry; Theodore J. Boritzki; Billy J. Roberts; Kenneth E. Hook; Wilbur R. Leopold
- Book ID
- 118372003
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 1003 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0065-2571
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๐ SIMILAR VOLUMES
CI-940, PD 114,721, and PD 118,607 are structurally novel antibiotics, which were isolated from fermentation beers of a previously unknown actinomycete. They are highly lipophilic acids characterized by unsaturated lactone and branched, polyunsaturated aliphatic side-chain moieties. All three agents
## Abstract Dermaseptins, small polycationic peptides synthesized by amphibians, exert a lytic action on bacteria, protozoa, yeast, and filamentous fungi at micromolar concentrations, but unlike polylysines, show little hemolytic activity. Dermaseptins S are active only against bacteria and form ag