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The bioactivation of 1,2-dibromoethane in rat hepatocytes: Deuterium isotope effect

โœ Scribed by Russell D. White; Thomas W. Petry; I.Glenn Sipes


Book ID
113136778
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
479 KB
Volume
49
Category
Article
ISSN
0009-2797

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The nematocide, grain fumigant, and gasoline additive 1,2-dibromoethane (DBE) is both a cellular and a genetic toxin that is metabolically activated in rats and mice by mixed function oxidases (MFO) as well as glutathione S-transferases (GST). The purpose of this study was to determine whether DBE i