Insulin-like growth factors, IGF-I and IGF-II, are potent regulators of oligodendrocyte development. Most of the IGF present in vivo is bound to members of a family of six high-affinity IGF-binding proteins (IGFBPs), which can either potentiate or inhibit IGF action, depending on other conditions. A
The binding of insulin to cerebral capillaries and astrocytes of the rat
✍ Scribed by Jan Albrecht; Barbara Wróblewska; Mirosław J. Mossakowski
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 467 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0364-3190
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## Abstract Insulin‐like growth factors (IGFs) protect neurons, are important for oligodendrocyte survival and myelin production, and stimulate the proliferation of astrocytes. The effects of IGFs are regulated by a family of IGF binding proteins (IGFBPs). Astrocytes express predominantly IGFBP‐2.
Rat cerebral astrocytes from confluent primary cultures were grown for two weeks in medium made hyperosmotic with additional NaCI. At the time the cells were harvested (four weeks in culture), the medium osmolality of experimental cultures was approximately 600 mOsm. Amino acid, protein, and potassi