The binding of ibuprofen to plasma proteins
β Scribed by L. Aarons; D. M. Grennan; M. Siddiqui
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 343 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0031-6970
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π SIMILAR VOLUMES
The enantioselective protein binding of mephobarbital (MPB) was investigated in human plasma and human serum albumin solutions by equilibrium dialysis. A small but statistically significant difference was observed in the in vitro plasma protein binding of the enantiomers; (S)-MPB was -59% bound and
The binding of racemic zopiclone (ZOP) and of its two enantiomers to plasma proteins, albumin and β£1-acid glycoprotein were compared. Our work shows that the binding of ZOP to human plasma proteins is stereoselective. The total plasma protein binding percentages were 79.3 Β± 5.5%, 83.8 Β± 5.2%, and 75