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The binding of BmK IT2, a depressant insect-selective scorpion toxin on mammal and insect sodium channels

✍ Scribed by Ya-Jun Li; Zhi-Yong Tan; Yong-Hua Ji

Book ID
117363757
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
190 KB
Volume
38
Category
Article
ISSN
0168-0102

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BmK AS: New scorpion neurotoxin binds to
BmK AS: New scorpion neurotoxin binds to distinct receptor sites of mammal and insect voltage-gated sodium channels
✍ Ya-Jun Li; Yan Liu; Yong-Hua Ji πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 168 KB

This study was undertaken to assess the binding properties of BmK AS on both mammal and insect excitable cell membranes. It was found that BmK AS bound specifically to a single class of non-interacting binding sites on both rat brain and cockroach nerve cord synaptosomes with high affinity (K d Ο­ 1.