✦ LIBER ✦
The binding of 99mTc(Sn)-MDP complexes to human serum albumin and other blood proteins determined with gel chromatography and ultrafiltration
✍ Scribed by Y.M. Huigen; T.G. Tji; W.J. Gelsema; C.L. de Ligny
- Publisher
- Elsevier Science
- Year
- 1989
- Weight
- 365 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0883-2889
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✦ Synopsis
The binding of 99mTc(Sn)-MDP to human serum albumin and other blood proteins was investigated by gel chromatography and ultrafiltration. During gel chromatography dissociation of the 99mTc(Sn)-MDP-protein complex occurs: thus, it is not a suitable technique for the determination of protein binding. The values found with ultrafiltration have to be corrected for non-ultrafiltrable TcO2.nH2O. From the corrected values it can be concluded that binding of 99mTc(Sn)-MDP to blood proteins does not play a role in the biodistribution.