The binding activity of Mel-18 at the Il17a promoter is regulated by the integrated signals of the TCR and polarizing cytokines

RORγT, a thymus-specific isoform of the

RORγT, a thymus-specific isoform of the orphan nuclear receptor RORγ / TOR, is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoter

✍ Isabelle Villey; Régina de Chasseval; Jean-Pierre de Villartay 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB 👁 1 views

TEA (T early alpha) is a genetic element located upstream of the TCR-J § cluster. Thymocytes from mice carrying a targeted deletion of TEA do not rearrange their TCR § locus on a window spanning the first nine J § segments. This led us to the hypothesis of TEA having a "rearrangement focusing" activ