The Big Book on Small Heat Shock Proteins

✍ Scribed by Robert M. Tanguay, Lawrence E. Hightower (eds.)

• Publisher: Springer International Publishing
• Year: 2015
• Tongue: English
• Leaves: 603
• Series: Heat Shock Proteins 8
• Edition: 1
• Category: Library

✦ Synopsis

Based upon a workshop entitled “The Small HSP World” held in Québec 2-5 October 2014. Twenty-five scientists provided chapters for the book. The chapters are from the best scientists currently working in this field. These colleagues include Arrigo, Benesch, Benjamin, Buchner-Haslbeck-Weinkauf, Benndorf, Boelens, Carra, Chang, Currie, Ecroyd, Emanuelsson, Fu, Garrido, Golenhofen, Gusev, Hightower, Kampinga, Lavoie, MacRae, Quinlan, Tanguay, Vierling, Vigh, Weeks and Wu. Briefly, the book starts with the structure of small heat shock proteins, moving to their functions and finishing with their involvement in diseases. Although this is quite broad, the structural aspect will be the unifying theme of the book.

✦ Table of Contents

Front Matter....Pages i-ix
Front Matter....Pages 1-1
The Multicolored World of the Human HSPB Family....Pages 3-26
Immense Cellular Implications Associated to Small Stress Proteins Expression: Impacts on Human Pathologies....Pages 27-83
Front Matter....Pages 85-85
Dynamics-Function Relationships of the Small Heat-Shock Proteins....Pages 87-100
Insights into How Small Heat Shock Proteins Bind a Great Diversity of Substrate Proteins: A Super-Transformer Model....Pages 101-117
Model Chaperones: Small Heat Shock Proteins from Plants....Pages 119-153
Regulation of the Chaperone Function of Small Hsps....Pages 155-178
Redefining the Chaperone Mechanism of sHsps: Not Just Holdase Chaperones....Pages 179-195
Everything but the ACD, Functional Conservation of the Non-conserved Terminal Regions in sHSPs....Pages 197-227
HSPB6 (Hsp20) as a Versatile Molecular Regulator....Pages 229-253
The Chloroplast-Localized Plant sHsp in Arabidopsis Thaliana: Role of Its Oligomeric Conformation and Its Translocation into Membranes....Pages 255-266
Front Matter....Pages 267-267
Multifunctional Roles of αB-Crystallin in Skeletal and Cardiac Muscle Homeostasis and Disease....Pages 269-299
Role of Small Heat Shock Protein HspB5 in Cancer....Pages 301-314
Small Heat Shock Proteins and Fibrosis....Pages 315-334
Neurodegenerative Diseases, Sex Differences and the 27 kDa Heat Shock Protein in the Nervous System....Pages 335-363
HspB5/αB-Crystallin in the Brain....Pages 365-381
Small HSP Variants and Human Diseases....Pages 383-397
Front Matter....Pages 399-399
The Dynamic Duo of Small Heat Proteins and IFs Maintain Cell Homeostasis, Resist Cellular Stress and Enable Evolution in Cells and Tissues....Pages 401-434
Regulation of Actin-Based Structure Dynamics by HspB Proteins and Partners....Pages 435-456
Heat Shock Alters Keratocyte Movement and Morphology: Exploring a Role for HSP27 (HSPB1)....Pages 457-469
Reconsidering Old Data: Non-canonical HspB1 Species and the Enigma of the Cytoskeletal Function of HspB1....Pages 471-485
Front Matter....Pages 399-399
Role of HSPB8 in the Proteostasis Network: From Protein Synthesis to Protein Degradation and Beyond....Pages 487-510
Understanding What Small Heat Shock Proteins Do for Bacterial Cells....Pages 511-525
How to Stabilize Both the Proteins and the Membranes: Diverse Effects of sHsps in Neuroprotection....Pages 527-562
Back Matter....Pages 563-578
....Pages 579-606

✦ Subjects

Biomedicine general; Protein Science; Cell Biology