THE BELGIAN SOCIETY FOR CELL BIOLOGYBELGIAN CELL BIOLOGY. TOWARDS THE 21st CENTURY. SILVER JUBILEE MEETING: 25 October 1997, University Centre of Diepenbeek
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 340 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1065-6995
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✦ Synopsis
Recurrent chromosomal rearrangements involving 12q14-15 have been observed in a large group of benign tumours including, lipomas, uterine leiomyomas and salivary gland adenomas. Recently our group has shown that these rearrangements often involve the HMGIC (high mobility group) gene, resulting in aberrant expression or fusion transcripts of HMGIC. In lipomas, the LPP (lipoma preferred partner) gene has been identified as the preferential translocation partner for HMGIC. The HMGI proteins are implicated in transcriptional regulation. They function as architectural factors required for the correct assembly of protein-DNA complexes at promoters. Expression of the HMGIC gene is tightly linked to growth; HMGIC is mainly expressed during early development and in growing cells, it responds to serum induction as a delayed early gene and homozygous disruption of the HMGIC gene in mice leads to the pygmy phenotype. The main aim of this project is to study the function of HMGI-C in growth and development and to determine its role in benign tumour formation. The regulation of HMGIC expression during the cell-cycle and its regulation by growth factors will be discussed.