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The behavioural effects of RU 24969, a suggested 5-HT1 receptor agonist in rodents and the effect on the behaviour of treatment with antidepressants

โœ Scribed by A.R. Green; A.P. Guy; C.R. Gardner

Book ID
118955069
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
776 KB
Volume
23
Category
Article
ISSN
0028-3908

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โœ G. M. Goodwin; Rosemarie J. Souza; A. R. Green ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Springer ๐ŸŒ English โš– 557 KB

The effects of 2-(4-(4-(2-pyrimidinyl)-l-piperazinyl)-butyl)-1,2-benzoisothiazol-3(2H)one-1,1-dioxide hydrochloride (isapirone, TVX Q 7821), a putative 5-HT1 receptor antagonist, has been studied on various models of 5-HT receptor sub-type function. In mice TVX Q 7821 produced a dose-dependent inhib