The behavioral pharmacology ofSch 12679. A new psychoactive agent

✍ Scribed by Allen Barnett; Robert I. Taber; Solomon S. Steiner

• Book ID: 104769131
• Publisher: Springer
• Year: 1974
• Tongue: English
• Weight: 565 KB
• Volume: 36
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00422560

✦ Synopsis

Sch 12679, N-methyl-Lphenyl-7,8-dimethoxy-2,3,4,5-tetrahydro-3benzazepine maleate, is active in a broad spectrum of laboratory models of aggressive behavior without producing any signs of neurotogic impairment up to lethal doses. Sch 12679 is an effective inhibitor of isolation-induced aggression in mice, murieide and septal lesion-induced aggression in rats and spontaneous aggression in Rhesus monkeys. Sch 12679 also antagonizes methamphetamine aggregate toxicity in mice and hypothalmic self-stimulation in rats as do major tranquilizers; however, it differs from major tranquilizers in that it does not affect conditioned avoidance response (CAR) performance or produce catalepsy, ptosis or hypothermia.

~%h 12679 does not fit into established profiles for either minor or major tranquilizers or other existing types of psyehopharmacological agents. Initial clinical studies have confirmed that Sch 12679 reduces aggressive behavior without producing concomitant sedation.