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The behavioral effects of depletions of brain serotonin induced by 5,7-dihydroxytryptamine vary with time after administration

✍ Scribed by Paul F. Gately; David S. Segal; Mark A. Geyer

Book ID
119505457
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
690 KB
Volume
45
Category
Article
ISSN
0163-1047

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Effects of i.c.v. administration of 5,7-dihydroxytryptamine (5,7-DHT) on biochemistry and behavior were studied in awake Sprague-Dawley rats. It was found that 5,7-DHT depletion of striatal tissue levels of serotonin (5-HT) does not diminish extracellular levels until substantial depletions occur. T