Treatment of Philadelphia-chromosome-pos
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Yoshio Honma; Yoshinobu Matsuo; Yasuhide Hayashi; Satoshi Omura
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Article
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1995
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John Wiley and Sons
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French
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The molecular basis of the Philadelphia chromosome (Ph') is a structurally altered c-abl (bcr-abl) gene which encodes an abnormally large protein with protein tyrosine kinase activity. Herbimycin A, which effectively reduced intracellular phosphorylation by bcr-abl tyrosine kinase, preferentially in