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The Bcr-Abl tyrosine kinase inhibitor imatinib and promising new agents against Philadelphia chromosome-positive leukemias

โœ Scribed by Taira Maekawa; Eishi Ashihara; Shinya Kimura


Book ID
106284998
Publisher
Springer
Year
2007
Tongue
English
Weight
495 KB
Volume
12
Category
Article
ISSN
1341-9625

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โœ Yoshio Honma; Yoshinobu Matsuo; Yasuhide Hayashi; Satoshi Omura ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 731 KB

The molecular basis of the Philadelphia chromosome (Ph') is a structurally altered c-abl (bcr-abl) gene which encodes an abnormally large protein with protein tyrosine kinase activity. Herbimycin A, which effectively reduced intracellular phosphorylation by bcr-abl tyrosine kinase, preferentially in