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The Bcr-Abl mutations T315I and Y253H do not confer a growth advantage in the absence of imatinib

✍ Scribed by Miething, C; Feihl, S; Mugler, C; Grundler, R; von Bubnoff, N; Lordick, F; Peschel, C; Duyster, J


Book ID
110056672
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
340 KB
Volume
20
Category
Article
ISSN
0887-6924

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Fusion of the BCR and the fibroblast gro
✍ Thoas Fioretos; Ioannis Panagopoulos; Carin Lassen; Agneta Swedin; Rolf BillstrΓΆ πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 305 KB

## Abstract Constitutive activation of tyrosine kinases as a consequence of chromosomal translocations, forming fusion genes, plays an important role in the development of hematologic malignancies, in particular, myeloproliferative syndromes (MPSs). In this respect, the t(9;22)(q34;q11) that result