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The base promoted oligomerization of a 15-dehydro-PGB1 analog: Structural insights into the complex oligomeric mixture termed PGBX

✍ Scribed by George L. Nelson; Gregory L. Verdine

Publisher: Elsevier Science
Year: 1982
Tongue: French
Weight: 288 KB
Volume: 23
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)87235-4

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✦ Synopsis

Ihe base promoted oligomerization of the l_+dehydro-F'GB analog 2 takes place by a Michael addition pathway involving multiple nucleophilic and acceptor sites.

Currently, the term PGBx refers to a complex mixture derived from treatment of lj-dehydro-PGa methyl ester (L) with 1 M ethsnolic KOH.' A number of unique properties have been demon-

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The base promoted oligomerization of 15-

The base promoted oligomerization of 15-dehydro-prostaglandin B1: dimer formation and structural implications for a complex mixture termed PGBx

✍ George L. Nelson; Gregory L. Verdine 📂 Article 📅 1983 🏛 Elsevier Science 🌐 French ⚖ 323 KB

The base promoted oligomerization of 15-dehydro-PGB1\_ (la) results in the formation of six dimers via a Michael addition pathway. The simultaneous operation of multiple reaction sites as required by dimer formation has major consequences for the structural complexity of the oligomeric mixture PGBx.