𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The “Azirine/Oxazolone Method” under Solid-Phase Conditions

✍ Scribed by Simon Stamm; Heinz Heimgartner

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
181 KB
Volume
2004
Category
Article
ISSN
1434-193X

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

The ‘Azirine/Oxazolone Method’ on Solid
The ‘Azirine/Oxazolone Method’ on Solid Phase: Introduction of Various α,α-Disubstituted α-Amino Acids
✍ Simon Stamm; Anthony Linden; Heinz Heimgartner 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 German ⚖ 260 KB

Peptides containing various a,a-disubstituted a-amino acids, such as a-aminoisobutyric acid (Aib), 1-aminocyclopentane-1-carboxylic acid, a-methylphenylalanine, and 3-amino-3,4,5,6-tetrahydro-2Hpyran-3-carboxylic acid have been synthesized from the N-to the C-terminus by the 'azirine/oxazolone metho

Synthesis of the protected 6–16 segment
Synthesis of the protected 6–16 segment of zervamicin II-2, an application of the azirine/oxazolone method
✍ Nicolas Pradeille; Heinz Heimgartner 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 158 KB

## Abstract The protected 11 amino acid segment (6–16) of the peptaibol zervamicin II‐2 was synthesized by using the ‘azirine/oxazolone method’ for the introduction of all Aib residues. Whereas a 2,2‐dimethyl‐2__H__‐azirin‐3‐amine was used as the building block for Aib(7), methyl 2,2‐dimethyl‐2__H_