The Autoxidation of Tensides I: The Autoxidation, Toxicity and Reclamation of Dianhydro Mannitol Mono-Oleate
✍ Scribed by Amer, M. M. ;Kader, Abdel ;Ahmad, S. ;Varda, S. P.
- Publisher
- John Wiley and Sons
- Year
- 1969
- Weight
- 353 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0931-5985
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✦ Synopsis
Dianhydro mannitol mono-oleate, a surfactant used in the preparation of water-in-oil injectable pharmaceutical preparations was found to autoxidize on storing, with the formation of free acidity and labile peroxides. The autoxidized substance was found to cause peritoneal adhesions when injected intraperitoneally in mice. The autoxidized material could be reclaimed by chromatography through alumina. The eluate was comparable to normal saline in toxicity and the adsorbate was found to be more toxic.
Autoxydation von Tensiden I: Die Autoxydation und Toxizitat von Dianhydromannit-monooleat
Dianhydromannit-monooleat, das als oberflahenaktiver Stoff bei injizierbaren W/O-Emulsionen in pharmazeutischen Praparaten verwendet wird, autoxydiert bei der Lagerung unter Bildung von freien Sauren und labilen Peroxyden. Es zeigte si&, daD bei intraperitonealer Injektion die autoxydierte Sub